A highly efficient synthesis of biologhically active spirooxindole derivatives with Nano SiO2 as a mild catalyst under solvent-free conditions

In this protocol, we have reported Nano SiO2 as an efficient and environmentally benign naturecatalyst for the multi-component efficient synthesis of biologically spirooxindole derivatives. And we studied three-component, one-pot condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1, 3-dicrbonyl compounds, naphthol and 4-hydroxycumarin under thermal and solvent-free conditions in the presence of Nano SiO2 as a mild catalyst. solvent-free conditions, short reaction times, good yields, non-toxic, in expensive, simple operational procedures, one-pot, mild, easily separated from the reaction mixture with no column chromatographic separation for the economical synthesis of these fused biologically compounds are the major advantages of this literature.

کلیدواژه ها:

Nano SiO2 ، Spirooxindole derivativesm Multi-component reactions ، Solvent-free conditions