PTPN221858C>T gene polymorphisms in Alopecia Areata: A case–control association study in Iranian population
سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 504
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شناسه ملی سند علمی:
MPHBS01_086
تاریخ نمایه سازی: 22 آبان 1395
چکیده مقاله:
Introduction: Alopecia Areata (AA) is an autoimmune disease characterized by well-circumscribed patches of hair loss especially from the scalp. The gene encoding the protein tyrosine phosphatase, non-receptor type 22 (PTPN22), which is exclusively expressed in immune cells, has been considered as a risk factor associated with a number of autoimmune diseases. The current study has been performed to investigate whether the PTPN221858C>T SNPs predispose to Alopecia Areata in Iranian patients. Materials and methods: The study group comprised 30 patients (13 female and 17 male with mean age 26.3 ±12.5 years) with Alopecia Areata and 15 healthy controls (5 Female and 10 Male with mean age 30.1 ±5.8 years). Genomic DNA was extracted from whole blood using DNG-Plus method. All individuals were genotyped for PTPN22 polymorphisms using the PCR–RFLP analysis. Results: PCR-RFLP results showed that TT was most frequent genotype in both patient and control groups (OR=3.5, 95%CI= 0.3-32.1, p value>0.05). CT genotype was detected in 6.7% and 13.3% of patients and controls, respectively (OR=0.4, 95%CI=0.05-3.67, p value>0.05). Genotype CC was detected in 73.3% of patients and 80% of controls (OR=0.6, 95%CI=0.15-3.08, p value>0.05). Conclusion: The PTPN22 C1858T is not relevant in susceptibility to AA in the Iranian population.
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نویسندگان
Reyhaneh Abgoon
Biology Department, East Tehran Branch, Islamic Azad University, Tehran, Iran
Reza Akbarzadeh
Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran
Akram Sadat Tabatabaei Panah
Biology Department, East Tehran Branch, Islamic Azad University, Tehran, Iran