The protective effect of Sargassum tenerrimum algae on hematological parameters fatty liver in mice

Introduction: The aim of this study was to evaluate the protective effect of Sargassum tenerriumum algae against the fatty liver which is induced by high fat diets in mice. Materials and methods: Mice were categorized in control (standard diet), experimental 1 (high fat diet), experimental 2 (high fat diet as well as Sargassum tenerriumum) and positive control (high fat diet along with simvastatin) groups. Mice in terms of changes in serum lipid profile and biomarkers of liver injury were compared. Levels of serum lipid profile to assess metabolic disorders, alanine aminotransferase and aspartate aminotransferase and bilirubin to assess liver damage, liver bile were measured to assess performance. Results: Results showed that after eight weeks of treatment, high fat diet causes metabolic adverse effects, including hypertriglyceridemia, hypercholesterolemia liver. Mice that were fed a high fat diet, increase activity in hepatocytes and the treatment of Sargassum in the plasma showed a significant decrease in the level of liver enzymes compared to other groups (p<0/05). Conclusion: Nonalcoholic fatty liver disease as a global problem, affecting humans, usually with obesity, hyperlipidemia, and diabetes mellitus type 2 is associated since Sargassum contains minerals and bioactive compounds such as antioxidants are vitamins and thus, Since the results of this study showed the decrease of hematological parameters in mice, it’s possible to introduce this algae as a proper drug complement in order to treat fatty liver.

کلیدواژه ها:

Hematological parameters ، Fatty liver ، Sargassum tenerriumum algae