The effect of 8 weeks resistance exercise on serum Irisin level and it's relation to body composition in prediabetic women

Introduction: Prediabetes is a high-risk state for diabetes with glycemic variables more than normal, lower than diabetes threshold. Prediabetes is rapidly increasing in the world, especially industrial countries. Myokines like Irisin that has discovered, newly has a role in regulating energy metabolism by inducing white adipose tissue to brown adipose tissue and can be improved glycemic condition. Therefore, we are investigating the effect of a period of resistance exercise on serum Irisin level and it's relation to body composition in prediabetic women. Materials and methods: Twenty adult, inactive, prediabetic women, 20 to 45 years old, have participated in this study. Then, volunteers randomly divided into two groups: Control and Experiment. The latter group took part in resistance exercise with 60% to 85% of 1RM, about 8 weeks and 3 sessions, every week. Each session consists of 10 minutes warm up, 40 minutes resistance exercise and 10 minutes of cooling down. Blood samples were taken, before and after 8th week exercise and the serum Irisin was analyzed 24 hours later. In addition, body composition measurement also was done before and after exercise. Statistical analysis of the data was done by IBM SPSS Statistic 22 software. The data statistically analyzed using paired sample T test. Results: The results showed a significant decrease in Irisin and body composition after 8 weeks resistance training in prediabetic women. Resistance exercise decreased weight, BMI, body fat mass, WHR significantly, but soft lean mass didn't change significantly. There were no relation between Irisin decrease and cardiovascular risk factors. Conclusion: We conclude that 8 weeks resistance exercise does not increase serum Irisin in prediabetic women, but this kind of exercise was effective in reducing cardiovascular risk factors. Moreover, there is not a significant relationship between Irisin and cardiovascular risk factors after 8 weeks resistance exercise.

کلیدواژه ها:

Irisin ، Prediabetes ، Body composition