Comparison between acute effects of intermittent hypoxia and aerobic exercise on nitric oxide level, blood pressure and lung function in apnea

Introduction: Sleep apnea is a form of respiratory disorders and a common health problem. Studies report that, Regular physical activity, including aerobic exercise is non-pharmacological strategies for treatment of sleep disorders and apnea. Doing regular exercise hypoxia and also practicing, has been suggested to reduce stress resting blood. Materials and methods: 12 male volunteers with obstructive sleep apnea (_24.54+-10.24 old) performed an aerobic exercise consisted in 40 minutes by running on treadmill with intensity of 70% heart rate reserve. During intermittent hypoxia session, 5 minutes hypoxic air (11% oxygen) and 5 minutes normoxic air (room air) were inhaled intermittently at sitting position for an hour in separate days. Before the test, half-hour and hour after the intervention, measures of lung function (FVC, FEV1, TV, PEF, FEV1.VC). Also blood pressure measured 20 minutes after the subjects in laboratory. After that the practice time was measured every ten minutes to an hour. Blood samples before and immediately after exercise collected to measure the levels of nitric oxide. To determine. The normality of the distribution of test data Kolomogrov-Asmirnov and analysis of variance with repeated measurement was used to analysis. Results: Nitric oxide levels increase and Systolic and diastolic blood pressure levels reduced significantly after aerobic exercise and intermittent hypoxia. However, nitric oxide, Systolic, blood pressure at 40,50and60 minutes ،and diastolic blood pressure in 60 minutes, decreased significantly only in intermittent aerobic exercise (P≤0.05). Reduction in systolic blood pressure at 50 minutes was significantly correlated with the PEF post 30 and 60 minutes (P≤0.05). Conclusion: In general, it can be concluded that an aerobic exercise protocol of the hypoxia periodic activity, nitric oxide and blood pressure systolic and diastolic in patients with obstructive sleep apnea improves. Communication systolic blood pressure in 50 minutes with indicator PEF half an hour after exercise represents improved distention lung after workout. Application seems to be 40 minutes of aerobic exercise at 70% heart rate reserve, a major factor in response to nitric oxide, blood pressure and dilates lung after exercise. This method has less limitations in comparison with regular exercise at the same time and expected to fulfill the aim, the regular practice for a wider range of people, including the sick, disabled and older applicant

کلیدواژه ها:

Nitric oxide ، Hypoxi ، Aerobic exercise ، Acute ، Lung function ، Blood pressure ، Apnea