Short-term effect of consumption Cistanche tubulosa for treating Alzheimer’sdisease

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 646

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شناسه ملی سند علمی:

MPHBS01_164

تاریخ نمایه سازی: 22 آبان 1395

چکیده مقاله:

Introduction: Alzheimer’s disease (AD) is a chronic neurodegenerative disease which associates with loss of shortterm memory. This study was conducted to survey the effect of Cistanhce tubulosa extract (CTE) on short-term treatment of AD.60 adult-male-Wister rats divided into 6 groups. Materials and methods: In the first group 10 healthy rats were served as negative control (T1). Treatments 2 to 6 received 17 mg/kg Aluminum chloride (intragastric) for 30 successive days in order to induction of Alzheimer. T2 was positive control, T3 received 0.3 mg/kg ofRivastigmine tartrate (Exelon®) daily, and T4, T5 and T6 received 100, 200 and 400 mg/kg of ethanolic CTE for 14 days, respectively. T-maze test was done 14 days after induction. Results: Results indicated that T2 (75.33±17.74) had statistically significant difference with other treatments (P<0.05). Also, all treatments which received CTE required shorter time to arrive destination compared to T2 and T3, but T5 (38.413.8) and T6 (23.44.82) had statistically significant difference with T3 (P<0.05). Only T6 had not a significant difference in comparison to T1.Results indicated a dose dependent effect of CTE on improving AD in short-term consumption. Literature reviewed showed CT has great antioxidant capacity and anti-inflammatory properties. Also, it is indicated that CTE helps improving the ability to elicit or recall memorized information. Conclusion: These findings indicate that CTE can protect nerve cells by regulating the expression of apoptosis-related factors and neuro-trophic factors and also it can improve neural regeneration. Thus, CTE could prevent and treat AD by neutralize and reduce free radicals and inflammatory agents.

نویسندگان

Mohammad Sadegh Ghodrati

DVM Student, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Saeideh Naeimi

Assistant Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan,Iran.

Alireza Moshtaghi

DVM Student, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Rasoul Rostami Lima

Labratory Technician, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.