Cinnamon essential oil and zinc sulfate complex, efficiently decreased glucose concentration and stimulated insulin secretion in Streptozotocin-induced diabetic rats

Introduction: Diabetes is one of the fifth major causes of death in the world that needs so much attention. Today, researchers are trying to find natural products, such as herbs and their derivations, for treatment of different disorders and diseases. Cinnamon (Cinnamomum zylenicum) is commonly used in the food industry because of its special aroma. Considering sugar reducing properties of cinnamon. We hypothesized that a combination of sulfated zinc and cinnamon essential oil (CEO) are more efficient compared to the single form of CEO. Thus, this study was conducted to study the effects of cinnamon essential oil (CEO) and zinc sulfate on glucose and insulin concentration in Streptozotocin-induced diabetic rats. Materials and methods: Male Wistar rats, weighing 250 ± 50 g, were used. Diabetes induced by single i.p. injection of streptozotocin at dose of 60 mg/kg. The animals were i.p. received 1) 0mg/kg CEO or zinc sulfate, 2) 50 mg/kg zinc sulfate, 3) CEO100 mg/kg, 4) zinc sulfate 50 mg/kg +CEO 100 mg/kg. Each group contained 10 rats. The group receiving 0 mg/kg served as control group. Results: Our findings showed that treatment with CEO and zinc sulfate complex, reduced the serum concentration of glucose and increased the serum concentration of insulin compared to the control group. CEO and zinc sulfate complex is more useful than the single form of CEO, so that animals treated with complex of zinc sulfate and CEO, showed a significant (P<0.05) decrease and increase in serum concentration of glucose and insulin compared to the control group respectively, the effect which did not observe in CEO group. Conclusion: The combined form of zinc and CEO is better than CEO alone for diabetes treatment and this combination can be used traditionally for treating diabetes

کلیدواژه ها:

Cinnamon ، Glucose ، Rat ، Streptozotocin ، Zinc