The Effect of Fampridine on Cognition in Patients with Multiple Sclerosis

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 421

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شناسه ملی سند علمی:

MSC16_080

تاریخ نمایه سازی: 11 آذر 1398

چکیده مقاله:

Introduction: Farmridine, a voltage- dependent potassium channel blocker is indicated for the improvement of walking in patients with multiple sclerosis (MS) and with walking disability (EDSS 4-7). Recent studies shown that fampiridine has effects on cognition, fatigue, depression and quality of life in MS patents. Methods: A clinical study in outpatient MS clinic at a prospective non- interventional study was done. Patients receiving fampiridine in outpatient setting. In this study evaluate the effectiveness of fampridine on cognition of MS patients besides walking. 134 walking- impaired patients were treated with fampridine, cognitive evaluations were performed at its start and after six months.Results: MS patients with cognitive impairment at baseline or study start at six months of treatment, showed significant improvements in both physical and cognitive parameters.Conclusion: Fampridine has positive effects on cognitive functions in MS patients, and is drug which improves cognition, fatigue and depression at same time.

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نویسندگان

a Chitsaz,

MD. Professor of Neurology, Isfahan University of Medical Sciences