Investigation Risk Factors Associated with Congenital Hypothyroidism: A Case-Control Study in Southeast of Iran

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 416

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شناسه ملی سند علمی:

MSEMSMED12_192

تاریخ نمایه سازی: 22 دی 1396

چکیده مقاله:

Background and Objective: Congenital hypothyroidism ( CH ) is known as one of the most common preventable cause of mental retardation. This study aimed to determine factors associated with CH in Iran.Materials and Methods: This case-control study was conducted on 160 children under one year old in Zahedan in southeast of Iran in 2016. The neonates who were born from March 1, 2015 to March 19, 2016 and used of screening program for CH were the study population. The neonates with serum TSH > 10mIu/L and T4 < 6.5 or TSH > 30 mIu/L was considered as case group (case ). Each case was individually matched for sex, age at birth and place of residence with three neonates with normal TSH and T4 titers as control group. Data was gathered using a standard checklist and analyzed using SPSS 20 and statis tical tests, such as Chi-square and Fisher exact tests. Multivariable logistic regression analysis was used to identify independent predictors of CH.Findings: About 25 of the 40 patients with CH ( 62.5% ) were male that in the univariate analysis, the following explanatory factors had not significantly associated with CH: history of pa rental consanguinity, type of delivery, weight at birth, height at birth, age of mother, sampling time, nationality, and birth season ( p > 0.05 ). Although, multivariate analysis showed no significant association between the studied factors and risk of CH ( p > 0.05 ); However, the likelihood of CH was greater among neonates born to consanguineous parents [ AOR: 1.78, 95% CI ( 0.82 - 3.89 ) ], those who born to lower height at birth [ AOR:1.82, 95% CI ( 0.85 - 3.91 ) ], neonates born to mothers younger than 18 years [ AOR:2.43, 95% CI ( 0.57 - 10.29 ) ] and those who born to in summer [ AOR:1.76, 95% CI ( 0.57 - 5.44 ) ]. Conclusion: none of the studied factors were not predictor for CH. Since consanguineous marriages are frequent in the province, and it may be a major contributory factor; therefore, future studies should be conducted on the genetic causes.

کلیدواژه ها:

Congenital hypothyroidism ، Risk Factors ، Case - control studies

نویسندگان

Mohammad Khammarnia

Assistant Professor, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Fariba Ramezani Siakholak

Department of Epidemiology and Biostatistics, School of Public Health, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Maryam ghorbani

Department of Epidemiology and Biostatistics, School of Public Health, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran