Synthesis of Fe3O4 Magnetic Nanoparticles by Modified Coprecipitation Method and Investigation of TheirStructural, Microstructural, Magnetic, and Biocompatibility Properties

Recently, the iron oxides superparamagnetic nanoparticles (SPIONs) have beenconsiderably utilized in various biomedical applications such as MRI contrast agents,magnetic targeted drug delivery, and magnetic hyperthermia. In present work, the main aimsare focused on the synthesis of Fe3O4 nanoparticles with the appropriate desired propertiesby modified coprecipitation method. In order to control the synthesis process, the differentconcentration of NaOH and NH4OH solution were used as a reduction agent at the differentreaction temperatures. The structural, microstructural and magnetic properties of synthesizedparticles were carried out using X-ray diffraction (XRD), transmission electron microscopy(TEM), and vibration sample magnetometer (VSM) analyses, respectively. Furthermore, thebiocompatibility and toxicity properties of particles were studied by cell viability (MTT) assay.The results show that the coprecipitation can be used as an effective synthesis technique.Moreover, compared to NH4OH reduction agent, the utilization of NaOH solution is led tofabricate nanoparticles with relatively higher saturation magnetization (Ms) while thesynthesized powders in NH4OH solution demonstrate lower size and higher crystallinitydegree. Finally based on the MTT assay, it can be concluded that the synthesized particleshave acceptable biocompatibility, although the toxicity of particles is influenced by their size.

کلیدواژه ها:

Superparamagnetism ، Reduction Agents ، Microstructural Properties ، Biomedical Application ، Ferrite Structures