Significant correlation of EGFR Overexpression with clinicopathological features as a biomarker for Head andneck squamous cell carcinoma (HNSCC) Patients
محل انتشار: اولین سمپوزیوم بین المللی سرطان نسترن
سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 443
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شناسه ملی سند علمی:
NASTARANCANSER01_113
تاریخ نمایه سازی: 26 شهریور 1395
چکیده مقاله:
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancerworldwide. Different factors can cause HNSCC including tobacco smoking, alcoholconsumption, mutations in growth factor or receptor tyrosine kinase genes. Overexpression oftyrosine kinase receptors, deletion and changes within the chromosome or genomesequence is associated with hyperplastic lesion and recurrent in HNSCC. Overexpression ofreceptor tyrosine kinases genes and related transcription factor have important role in cellsignaling pathways and tumorigenesis. Our aim in this study was to analysis of epidermalgrowth factor receptor (EGFR) mRNA expression in HNSCC and assess its correlation withclinicopathological features of the patients. Normal and tumor tissues from 55 HNSCCpatients were enrolled in this study. After RNA isolation and cDNA synthesis, expression ofthe gene was analyzed using real time PCR.The mRNA expression of EGFR, was upregulated in HNSCC tissues compared with their margin normal tissues. Overexpression ofEGFR was observed in 23 of 55 (41.8 %) cases. There was significant correlation betweenmRNA expression and clinicopathological features. Overexpression of EGFR wassignificantly correlated with Lymph node metastasis (39.13%, P=0.029) and patients’Weight loss (56.52%, P=0.025). Based on these results and due to correlation of EGFRexpression with clinical features, the expression pattern of this gene may be considered as abiomarker for HNSCC progression and development. Furthermore, it may be goodtherapeutic target for cancer therapy of HNSCC
کلیدواژه ها:
Receptor Tyrosine Kinase ، EGFR ، Epidermal growth factor receptor ، Head and neck squamous cell carcinoma ، HNSCC ، biomarker ، overexpression
نویسندگان
Masoud Jamali
Department of Biology, Damghan branch, Islamic Azad University, Damghan, Iran
Ehsan Ebrahimi
Department of Biology, Damghan branch, Islamic Azad University, Damghan, Iran
Lssa Jahanzad
Department of Pathology and IRAN Tumor Bank , Imam Khomeini Hospital Complex, Tehran University of Medical Sciences Tehran, Iran
Mohammad Mahdi Forghanifard
Department of Biology, Damghan branch, Islamic Azad University, Damghan, Iran