Association Of IL-1B+3954 Polymorphism In Chronic Gastritis As Risk Factors Of Gastric Cancer Development

Epidemiological investigations indicated Helicobacter pylori are the major cause of chronicgastritis and intestinal type of gastric cancer. IL-1B gene has been proposed as key factors indetermining risk of gastritis and malignant transformation. Purpose of the study: We aimed todetermine if IL-1B+3954 polymorphism are associated with the risk of chronic gastritis in Iranianpopulation. 198 individuals who showed the symptoms of chronic gastritis with coexisting infectionof H. pylori participated in the case group. Individuals without chronic gastritis were selected asthe control group and we also confirmed the presence of anti-H. Pylori serum IgG in 321 controlsubjects. IL-1B+3954C/T polymorphism was analyzed through PCR-RFLP. Results: IL-1B+3954 TTwere associated with a high risk of gastritis [Odds Ratio (OR)] = 2.75, 95% Confidence Interval (CI) =(1.50-5.03) (P-value: <0.001). Our results indicate that +3954C> T polymorphism of IL-1B geneincrease susceptibility to inflammatory response of gastric mucosa H.pylori-infected patients andplays a significant role in the development of chronic gastritis and the initiation of carcinogenesis.