Comparison of survival rate between autologous and allogeneic bone marrow transplantation in the treatment of patients with acute lymphocytic leukemia and acute myelocytic leukemia: adjusted analysis with semiparametric model

Autologous and allogeneic bone marrow transplantation(BMT) or stem cell transplantation (SCT) are increasingly considered for treatment of patients with acute lymphoblastic leukemia(ALL) and acutemyelocytic leukemia(AML). The purpose of this study is to compare survival rate after autologous and allogeneic BMT in patients with ALL and AML. In a retrospective study, a total of 93 patients with ALL and AML who had received autologous and allogeneic BMT, registered in Hematopoeitic Stem Cell Research Center (from 2007 to 2016), Taleghani hospital, Tehran, Iran entered into this study.Kaplan-Meyer and ordinal logarithm methods were used to compare the survival rate between autologous and allogeneic BMT. Also, age, sex, blood group, types of leukemia, white blood cell (WBC) count at the time of diagnosis, CD34+ and total mononuclear cells (MNC) were analyzed. Modeling of data was carried out using STATA, version11, and Cox regression method. The mean age of the patients at diagnosis was 32.11 ± 10.32 years (range, 2-61 years) and 47 patients (50.5%) were male. The average follow-up period was about 20.29±22.58 months (range: 0.33-87.37). Out of 93 patients, %36.6 had ALL and %63.4 had AML. Allogeneic transplantation was performed in 72 (77.4%) patients while autologous transplantation was given to 21 (22.6%) patients. The mean (± standard deviation) survival time for allogeneic transplantation was 48.22±5.04 months while for autologous transplantation was 64.02±8.6 months. The multivariate Cox model showed that there was a significant relationship between age, logWBC and total MNC with leukemia survival rate. According to our data survival rates of patients with leukemia who was received autologous transplantation was greater than patients who were given allogeneic transplantation

کلیدواژه ها:

Blood Cancer ، Cell and Cancer ، Cancer Stem Cells ، Stem Cells and Cancer ، Cancer Treatment and Management