Bioinformatics analysis of has-mir-769 targetome pathway and its snp function in patients with burkitt lymphoma

cancer is a class of disease characterized by abnormal cells that grow and invade surrounding healthy cells in the body. There are over 100 different types of cancer, and each is classified by the type of cell that is initially affected.Micro RNA (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. So they could be used as prognostic biomarkers. The aim of our study is to expand current knowledge about molecular function of has-mir-769 and its SNP in Burkitt lymphoma cells by using bioinformatics tools. validated and predicted targets of has-mir-769 wereobtained from miRtarbase and miRwalk database respectively. UniGene and DIVID database were used for further analysis. MIRNASNP database predicts single nucleotide polymorphism in has-mir-769and its function.It is predicted that hsa-miR-769 acts as a critical tumor suppressor microRNA by inhibiting some important genes in sustained angiogenesis pathway. Our data manifested KEGGsignaling pathways pathway in cancer as the most statistical relevant pathways with hsa-miR-769 targetome. According to our data, hsa-miR-769 and its SNP may be involved in Burkitt lymphomaprognosis by altering regulation of angiogenesis and some vital signaling pathways mRNAs. To sum up, C allele in this location can have prognostic value for angiogenesis and metastasis phenotypes inpatients with gastric cancer

کلیدواژه ها:

Blood Cancer ، Gene and Cancer ، Cell and Cancer ، Cancer Stem Cells ، Cancer Genetics