Targeted cancer drug delivery via conjugating as1411 aptamer to drug-loaded nanoparticles

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 299

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NASTARANCANSER03_174

تاریخ نمایه سازی: 7 اسفند 1396

چکیده مقاله:

Despite advances in chemotherapy, radiotherapy, and surgical procedures, cancer remains one of the leading causes of death all around the globe. Targeted delivery of anticancer-loaded nanoparticles hasrecently been demonstrated to be an effective approach to specifically deliver anticancer drugs to the target cells. Targeted delivery reduces undesired effects associated with current chemotherapeutic drugs. Thus, the search for novel strategies to fabricate targeted cancer therapy is in great demand. AS1411 is a 26-base G-rich DNA oligonucleotide that functions as a nucleolin-binding aptamer with potential apoptotic induction activity. AS1411 was the first anticancer aptamer tested in humans which showed an excellent safety profile and disease stabilization and a few cases of long-lasting objective responses during phases 1 and 2 of clinical trials. AS1411 is also being widely used as a tumor targeting aptamer that can direct a variety of attached molecules or nanomaterials specifically to tumor tissues. Nucleolin is a 76 kDa transmembrane multifunctional protein which serves as the molecular target of AS1411 as it can bind selectively to G-rich DNA or RNA. Nucleolin is highly expressed in the plasma membrane of tumor cells comprising DU145 (prostate cancer cell line), MDA-MB-231, MCF-7 (breast cancer cell lines), 4T1 (murine metastatic breast cancer cell), A549 (lung cancer cell line) and HeLa (cervical cancer cell line). Several lines of evidence have confirmed that cell surface nucleolin may act together with protein complexes associated with tumorgenesis and angiogenesis. This suggests that nanoparticle- conjugated aptamer could enhance the cellular uptake and efficiency of the drug delivery, while reducing the side effects associated with the cytotoxic drugs

نویسندگان

Bahram Bahrami-Teimoori

Department Of Modern Sciences And Technologies, School Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran

Majid Rezayi

Department Of Modern Sciences And Technologies, School Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran