Therapeutic potential of curcumin in the treatment of esophageal squamous cell carcinoma

Esophageal cancer (EC) is the seventh case of cancer death in men and the eighth most prevalent cancer universal. Despite recent advances in Esophageal cancer treatment, overall survival in esophageal cancer patients still remains poor. It has been reported that the oxidative lesions of bile acids reflux play a critical role in etiology of esophageal squamous cell carcinoma (ESCC). In this regard, Curcumin, a natural antioxidant extracted from turmeric, has been illustrated to minimize the bile acids disadvantages. Here we provide an overview on the Therapeutic Potential of curcumin in the treatment of esophageal squamous cell carcinoma. A literature search in multiple databases including the therapeutic effect of curcumin in ESCC was performed. The following keywords were used in combination: esophagus squamous cell carcinoma or ESCC and Curcumin or novel formulated forms of curcumin . Curcumin has been indicated to serve inhibitory impacts on NF-κB and also plays a crucial role in promoting apoptosis, Apoptosis-independent death and drug accumulation in ESCC cells. Moreover, Curcumin reversely affected the effects of bile acid on COX2, sodium dismutase-1, and DNA damage in the esophageal cell lines. Additionally, Curcumin s inverse effect on the mitogenic role of prostaglandin E2 (PGE2), has been also reported. The anti-cancer, activity of curcumin has been shown in different studies, although its low bioavailability has limited its clinical application, indicating the need to identify novel forms of curcumin with higher absorption rate to enhance bioavailability.

کلیدواژه ها:

Cell and Cancer ، Nutrition and Cancer ، Cancer Genetics ، Cancer Treatment and Management ، Drugs and Cancer