The prognostic value of a genetic variant in cdkn2a in infected hpv women

Cervical cancer is among the most common diagnosed cancer in women. Despite extensive efforts in the identification of prognostic and predictive biomarkers, only a very small number of markers haveidentified. Several genetic variants in the 9p21 region have been identified to be associated with the risk of different cancers. The aim of present study was to explore the value of a genetic variant (rs10811661) in CDKN2A with risk of developing cervical cancer. This study comprises 64 cervical cancer patients and 247 healthy woman without cervical cancer. DNA was extracted, followed bygenotyping using TaqMan realtime PCR. The genotype frequency and allele distribution of cases and controls were analyzed using person distribution of cases and control were analyzed using persondistribution, X2 , t-test or multivariate analyses. Our data showed the genotypic frequency for TT, TC and CC are 61/6%, 27/7%, 11/1% in patient group and 70/7%, 25/5%, 3/6% in healthy group. Moreover our data showed that TT genotype in rs10811661 polymorphism in recessive genetic inheritance model was associated with increased risk for cervical cancer patient (e.g., OR: 1.3, 95%CI: 1.1-2.9, P =0.04). Our findings showed that patients with TT for rs10811661 polymorphism was associated with increased risk of cervical cancer. Further investigations are warranted in a larger population

کلیدواژه ها:

Cervical Cancer ، Gene and Cancer ، Cell and Cancer ، Cancer Genetics ، Cancer Treatment and Management