Background: Burns have impacts including medical, psychological, economic and social that involve patients and health care system. Epidemiologic factors of burns vary in different societies. While the effects of some burn variables on mortality rate, in similar circumstances, are expected to be universal. The present study was carried out to analyze the epidemiology, mortality, and current etiological factors of burn injuries.Methods: This cross-sectional study was conducted during a period of 6 years (from 2010 to 2015). Data were obtained by the analysis of medical records of patients hospitalized in the Imam Reza Burn Center in Mashhad, Iran. The data were recorded by the nurses and staffs in the burn ward. Results were analyzed by using SPSS 16 software, and statistical analysis was performed using descriptive (frequency percent) and chi-square tests. Non parametric test, Mann-Whitney U test was used for variables abnormal distribution. Potential confounder was adjusted. Univariate and Multivariate analysis was used to identify significant risk factors from candidate variables. Then, multivariable logistic regression modeling was used to calculate the crude and adjusted odds ratios and 95% confidence interval (CI), P value of<0.05 was considered statistically significant.Results: In our study, 1334 in-hospital burn patients were recorded. The mean age was 27 ± 5.67 years. The most common mechanism of burn was flame. The multivariable logistic regression modeling revealed, that the most important risk factors of patient mortality were length of stay (LOS) OR=1.009(95% CI: 1.001-1.018), age OR=0.9 (95% CI: 0.96-0.97), sex OR=0.4(95% CI: 0.3-0.5), percentage of burn regarding body surface (BBS) OR=0.9(95% CI: 0.93-0.94),degree of burns OR=0.9(95% CI: 0.89-0.98).Conclusion: The results of our study revealed a high incidence of burns among > 20 years old. Implementation of prevention programs should be designed for focusing chiefly on the domestic environment and the kinds of risks to which children are exposed in their everyday routine and parents should also be educated about how to supply entertainment that would keep children away from risks.