Hydrogel and its variants: review

Background and Aim : Burn Wound cares After a burn injury, skin loses its protective properties, leaving the body open to a number of complications. The gold standard treatment for burn wounds is autologous skin grafting; however, this may not always be an option, due to insufficient amounts of donor skin. Wound dressings can be used as a primary treatment in those patients who are unsuitable for skin grafting. Many different materials are used to make the dressings; current materials include hydrocolloids, alginates, hydrogels, collagen and hyaluronic acid. hydrogels have been shown to exhibit a great number of beneficial properties and are the most favorable for use in burns patients. (Dhaliwal et al., 2018) Methods : What are hydrogels Hydrogels are 3D hydrophilic networks that can hold significant amounts of water within their structure, without dissolving in water. They can offer a combination of favorable properties, including high absorbency of biological fluids, biocompatibility, biodegradability, stimuli-responsiveness, high storage capacity and release ability of small and large therapeutic molecules. Their tune able network density allows engineering their mechanical properties to get an optimal balance among softness, conformability, strength, swelling degree, permeability and barrier properties. (Ajovalasit et al., 2017)Results : Hydrogel variants By combining two polymers: pullulan, an inexpensive polysaccharide with antioxidant properties, and gelatin, a derivative of collagen with high water absorbency, Nicholas et al. created a novel inexpensive hydrogel—named PG-1 for pullulan-gelatin first generation hydrogel —suitable for skin substitutes. PG-1 showed excellent mechanical characteristics for use as a skin substitute. ( Nicholas et al. 2016) Xyloglucan-based hydrogel films have been synthetized and characterized in the prospect of producing wound dressings. Polyvinyl alcohol (PVA) and glycerol (Gro) were added to have an optimal combination of softness, conformability and resilience. Physical hydrogels have been transformed into permanent covalent hydrogels by reaction with glutaraldehyde (GA). (Ajovalasit et al., 2017) A novel hydrogel (HA-az-F127 hydrogel) formed by reacting hydrazide modified hyaluronic acid (HAAD) and benzaldehyde terminated F127 triblock copolymers (BAF127) was developed. The hydrogel with dynamic covalent chemically and micellar physically double crosslinked networks exhibited rapid gelation and shear thinning property. (Li et al., 2018) Conclusion : Polymeric hydrogel dressings were found currently a convenient for any wound and burn types regardless the wound-shape.(kamoun et al.2017) .

کلیدواژه ها:

Hydrogels ، Wound dressing ، Burn injury