The comparison of serum levels of IL-6, IL-10 and TNF-α in sera the post-burn with the sera shortly before death in burn patients

Background and Aim : The concentration of pro-inflammatory and anti-inflammatory mediators, such as cytokines, are increased after a severe injury. Several studies have shown an increase in cytokine levels of IL-6, IL-10, and TNF-α in burn patients. However, the association between increased levels of these cytokines with sepsis and then with the death of the patients is unclear. To evaluate the role of IL-6, IL-10, and TNF-α in the sepsis, this study aimed to compare serum levels of these cytokines in burn patients immediately after hospitalization and shortly before death. Methods : In 43 burn patients, who already expired, were determined the IL-6, IL-10, and TNF-α serum levels using chemiluminescence, and the data were analyzed using Wilcoxon Signed Ranks Test. The total body surface areas of the burn injury varied from 17 to 99%. Results : A significant increase of IL-6 (p-value = 0.000), IL-10 (p-value = 0.000), and TNF- (p-value= 0.036) levels were detected in the sera collected shortly before death than those sera after hospitalization. Conclusion : We conclude that increased levels of IL-10, IL-6, and TNF-α may correlate with an increased risk of sepsis, which leads to the death of patients. These cytokines could serve as a predictive clinical marker for sepsis.

کلیدواژه ها:

IL-10 ، IL-6 ، TNF-α ، Burn