Investigation of Gas6 gene expression in colorectal cancer

It is widely accepted that CRC develops via a series of genetic and epigenetic changes that lead to the transformation of normal mucosa into a premalignant polyp, and ultimately to a malignancy. Colorectal cancer incidence rates by stage show relatively steady trends over the 7-year period.About one-third of patients diagnosed with (CRC) have a family history of cancer, placing them and other family members at elevated risk for this disease. Change in bowel habits, general or localized abdominal pain, weight loss without other specific causes, weakness, iron deficiency and anemia are the most common symptoms, and depends on the location and stage of the primary tumor. Altered activity or expression of GAS6/TAM components has been detected in a variety of anthologies such as inflammation, coagulopathy, cancer, autoimmune disease, diabetic vascular disease, kidney disease, and chronic kidney failure.

کلیدواژه ها:

Gas6 ، CRC ، TAM ، gene expression