Investigation of Interaction Between Nilutamide anticancer and Nanotubes; A computational study

Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostatecancer. Nilutamide is a pure, nonsteroidal anti-androgen with an affinity for androgenreceptors. Consequently, Nilutamide blocks the action of androgens of adrenal andtesticular origin that stimulate the growth of normal and malignant prostatic tissue.Prostate cancer is mostly androgen-dependent and can be treated with surgical orchemical castration. To date, antiandrogen monotherapy has not consistently been shownto be equivalent to castration.computing of energy diversity acquires apply methods of Semi-Empirical and MonteCarlo will give us valuable data about nanotubes interactions. Computer simulations withthese methods can cause to further comprehension of the thermodynamic and kineticparameters of such peptides and create further seeing into the plan, production, andstructural changes of peptides in various processes. Hyperchem utilization of theMetropolis method. In our reading, Kinetic, potential and total energy were computed byMonte Carlo and Molecular Dynamic simulation.

کلیدواژه ها:

Nilutamide ، Anticancer ، Nanotubes ، Semi empirical ، monte carlo