The controversial role of serotonin transporter gene (SLC6A4) in the autism spectrum disorders

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 359

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شناسه ملی سند علمی:

NGCMED10_029

تاریخ نمایه سازی: 16 تیر 1397

چکیده مقاله:

Introduction: The role of the serotonin system in the pathogenesis andetiology of autism spectrumdisorders (ASD) is not clearly established.TheSLC6A4 gene encodes the serotonin transporter, a membrane protein thattakes up serotonin in pre-synaptic neurons. In the proportion of patients highlevels of platelet serotonin have been consistently found, and it is knownSLC6A4 variants modulate transporter reuptake function, therefore possiblyinfluencingautistic patients. In this study, theassociation of two SLC6A4polymorphisms, 5-HTTLPR in the promoter and intron 2 variable number oftandem repeats (Stin2), in a sample of Iranian Azari ASD patients wasevaluated.Method:5-HTTLPR and Stin2 polymorphisms of SLC6A4 gene in 79 samplesof Iranian Azari Turkish ASD patients and 100 healthy control individualswereamplified by PCR method.Results: No significant difference of 5- HTTLPR andStin2 alleles frequencyand genotypes werefound between ASD patients and healthy controls, (pvalue> 0 .05).Conclusion:These results indicate that specific variants at theSLC6A4 genedon’t significantly role in the ASD diseases.

نویسندگان

Mahmoud Reza Shekari Khanian

Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Liela Shekari Khanian

MSc in psychology, Ministry of Education, Tabriz, Iran

Sima Mansouri Derakhshan

Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran