A meta-analysis on the association of serum uric acid and pediatric metabolic syndrome

Introduction: Hyperuricemia is implicated in the pathogenesis of inflammatory diseases and metabolic disorders. Metabolic syndrome in childhood is the most important cause of different cardiovascular complications in adulthood. This study was aimed to examine the association between serum uric acid (UA) concentration and metabolic syndrome components in children. Design: For this meta-analysis and systematic review, related articles were gathered by searching the keywords uric acid, metabolic syndrome, hypertension, fasting blood sugar (FBS), hyperglycemia in English databases includes PubMed, Web of Science, Scopus, Google scholar. English observational and cohort studies performed on children or adolescents were included. Pooled relative risks (RRs) and corresponding 95% confidence interval (95%CI) were extracted. A random-effect model was used. Main Outcomes: On the basis of 34 eligible studies, the pooled correlation between UA with metabolic components including FBS (r = 24, 95% CI = 0.09 to 0.40) , fasting insulin (r = 26, 95% CI = 0.15 to 0.37) and hyperglycemia (r for triglyceride and UA = 0.23, 95% CI = 0.19 to 0.38) (r for HDL(high dencity lipoprotein) and UA = -0.28, 95% CI = -0.37 to -0.20) were significant. Also, the assessment showed significant association of both diastolic blood pressur (DBP) and systolic blood pressure (SBP) with UA (r for SBP and UA = 0.34, 95% CI = 0.24 to 0.43) (r for DBP and UA = 0.18, 95% CI = 0.11 to 0.25), respectively. Besides, odds ratio between risk of abdominal obesity with UA was significant (OR = 2.62, 95% CI = 1.41 to 3.84). Conclusion: Serum uric acid concentration is associated with all components of the pediatric metabolic syndrome. Its measurement and control should be underscored in at-risk children and adolescents.

کلیدواژه ها:

metabolic syndrome ، hyperuricemia ، uric acid ، hypertension ، abdominal obesity ، hyperglycemia ، dyslipidemia.