Epigenetic sector the probable responsible for childhood obesity

Background: Adipogenesis is regulated by several adipocyte-selective miRNAs. The warning news from existing statistics in Iran indicate that waist circumference of children during 1999 to 2002 had grown up significantly (P value ≤ 0.0001). Methods: Childhood obesity is one of the most serious public health challenges for the 21st century. Recent articles, from PubMed had been reviewed about contribution of genetic sector for obesity of children and best candidates for miRNA and had been selected for obesity biomarkers. Results: Changes in miRNAs is also associated with leanness or obesity of generation and predict the newborns and next generation feature. Simply this prediction depends on the epigenetic and genetic makeup of children. Conclusion: It was found that a heterogeneous group of these molecules are associated with obesityin children. MiR-15b-5p, miR-486-5p, and hsa-miR-122-5p were considered as good candidates for obesity biomarkers. The miRNAs are potential biomarkers of the development of pathologies of obesity. Future molecular diets could be tailored by molecular adjustments to one s genetic innate properties and regulate characteristics of stem cells and hence govern fat cell numbers and adipose tissues generation properly. It seems that problem of the fatness for kids is beyond the regulation of energy intake.

کلیدواژه ها:

Micro RNA ، Waist circumference ، Obesity ، children ، biomarkers