The Importance of Using Ketogenic Diet for Epilepsy Treatment

Introduction: Drug- resistant epilepsy is a common pediatric neurological illness. pharmacological treatment with available anticonvulsants leads to seizure control in less than 70% of epileptic patients. Ketogenic diets (KDs) may be used as a supplementary therapeutic measure in different pathological condition, containing metabolic syndrome, diabetes mellitus(DM), polycystic ovarian syndrome, and certain neurological condition. KD is a therapeutic approach for refractory childhood epilepsy, which has reemerged as a robust alternative to anti-epileptic pharmacotherapy. The aim of this review was to evaluate ketogenic diet efficacy. Methods: PubMed, Scopus, Embase, and Google Scholar electronic databases were searched using the following keywords: ( Ketogenic Diet OR Diet OR diet therapy OR low glycemic index diet ) AND ( Epilepsy OR intractable epilepsy, ) to December 2019. Results: KDs operate via a combination of mechanisms, which are relevant to the effects of ketones and glucose restriction, and to interactions with receptors, channels, and metabolic enzymes. There is a growing body of evidence which supports the anti-seizure efficacy, safety profile and feasibility of KD use in childhood epilepsy. Conclusion: Clinical trials have provided undeniable evidence supporting the efficacy of KD in seizure control. cognition improvement and behavioral aspects of children and quality of life of parents are various other beneficial effects of KD. Pediatric and adult neurologists must be able to identify and refer appropriate patients to the KD as soon as necessary in the course of epilepsy instead of using it as a last option only.

کلیدواژه ها:

Ketogenic Diet ، Epilepsy ، Seizure Disorder ، Diet ،