Evaluation of Gentamycin polymeric electrospun nanofiber: as delivery for management of Periodontitis

Introduction:The purpose of the study was to formulate biodegradable intrapocket dental fiber which could be easily placed into the periodontal pocket, and be capable of delivering therapeutic dose. concentrations of Gentamycin for prolonged period of time with a much lowerMethods: PCL nanofibers containing Gentamycin were successfully electrospunand evaluated for periodontal diseases. PCL and GET in mixtures of DCM/N, N- DMF were prepared. Scanning electron microscopy (SEM) was used to investigate the morphology and average diameter of the nanofibers Findings:Nanofibers had a smooth and bead less morphology with the diameter ranging from 175 to 320 nm. DSC results indicated dispersion of GET in the PCL nanofibers and showed a decrease in crystallinity of PCL nanofibers by adding GET. Results showed that an increase in the DCM: DMF ratio led to a decrease in the solution conductivity and an increase in the solution viscosity and in the nanofibers diameter. In vitro drug release studies showed that the drug release rate was affected by the solvents ratio and the drug concentration. Sustained drug release was prolonged to 15 days.Conclusion: The prolonged drug release, together with proven biocompatibility, antibacterial and mechanical properties of drug loaded core shell nanofibers make them a promising candidate to be used as drug delivery system for periodontal diseases

کلیدواژه ها:

Nanofibers ، electrospun ، periodontitis ، PCL ، Gentamycin