Human Glioblastoma Stem Cells and Nano- Curcumin

Glioblastoma multiform (GBM) is a progressive brain tumor that causes mortality around the word. Current treatment is not successful because drug delivery is so poor. Recent evidences have shown that nanoformulating of drugs could be useful for treatment of GBM. Among different types of nano-particles, niosomes are biodegradable, biocompatible, and nonimmunogenic structure. On the other hand, today’s researchers have focused on natural components as an antitumor agents. Curcumin is introduced as a key and functional formof natural component in cancer biology. In the present study, we improved delivery of curcumin in the shell of niosome as a nano-carrier. To evaluate the anti-tumor effects of nano-curcumin, we treated glioblastoma stem cells (GSCs) with nano-curcumin. Our results showedthat nanno-curcumin decreased proliferation, migration, and invasion of GSCs. Furthermore, we showed that the increase of ROS generation and apoptosis in GSCs when treated with nano-curcumin. To summarize, nanocurcumin is more efficient than free curcumin and can beproposed for GBM treatment.