Effects of Moderate Treadmill Exercise and Fluoxetine on Mrna Expression of Apoptosis Related Protein in A Rat Model of Post-Traumatic Stress Disorder

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 411

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شناسه ملی سند علمی:

NIMED03_096

تاریخ نمایه سازی: 7 آبان 1398

چکیده مقاله:

traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selectiveserotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need for the development of new treatment. Physical activity is known to improve symptoms of certain neuropsychiatric disorders. The present study investigated the effects of moderate treadmill exercise, the antidepressant fluoxetine and the combined treatment on mRNA expression of apoptosis - related proteins in a rat model of PTSD: the single prolonged stress (SPS)model. Materials and Methods: Rats were exposed to SPS (restraint for 2 h, forced swimming for 20 min and ether anesthesia) and were then kept undisturbed for 14 days. After that, SPS rats were subjected to chronic treatment with fluoxetine (10 mg/kg/day, for 4 weeks), moderate treadmill running (4 weeks, 5 day per week) and the combined treatment (fluoxetine plus treadmill exercise), followed by apoptosis markersassessments. Results: This study showed that SPS significantly increased the mRNA expression of the protein Caspase-3 in the hippocampus, increase in apoptotic factor in hippocampus causing of cell death. We found that all treatments (fluoxetine, exercise and the combined treatment) down regulated Caspase-3 mRNA in the hippocampus, which shifted to the cell survival. Conclusion: The anti-apoptotic effects of the combined treatment (exercise + fluoxetine) were much stronger than those of either treatment alone, suggesting a synergistic effect between them in the hippocampus

نویسندگان

Zahra Hosseini Bajestani

Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

Pouya Darzi

Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

Reza Yakhkeshi

Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

Fatemeh Roshani

Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran