Neuroprotective Effects of Drugs Were Used in Diabetes Mellitus

The aim of the current study is investigation of the effect of combined intake of high dose of aspirin, atorvastatin, captopril and metformin onoxidative stress in the brain cortex and hippocampus of streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Rats were randomly divided into the following eleven groups: control and diabetic (D), as well as 9 groups that were treated with metformin(M, 300 mg/kg) or aspirin (ASA, 120 mg/kg) alone or in different combinations with captopril (C, 50 mg/ kg), or atorvastatin (AT, 40 mg/kg), as follows: (D+M), (D+ASA), (D+M+ASA), (D+M+C), (D+M+AT), (D+M+C+ASA), (D+M+C+AT), (D+M+AT+ASA), and (D+M+C+AT+ASA). The rats in treatment groups daily received drugs by gavage for six weeks. Finally, serum lipid profile and levels of oxidative markers in the brain cortex and hippocampus tissues were evaluated. Results: The level of MDA in cortex and hippocampus in all treated groups significantly decreased (p<0.05). There was significant increase in total thiol concentration as well as catalase activity in treated rats with M+AT, M+C+ASA, M+C+AT, M+AT+ASA and M+C+AT+ASA groups in cortex and hippocampus in comparison with the diabetic rats (p<0.05). Also, the SOD activity in all treated rats with drugs significantly boosted compared to the diabetic rats (p<0.05-p<0.01). Conclusion: Our findings were showed that combined use of high dose of aspirin, metformin, captopril and atorvastatin potentiate their antioxidant effects on the brain and also have improvement effect on the cognitive functions with their neuroprotective effects on hippocampus area.