Feeding Vitamin C During Neonatal and Juvenile Growth Improve Learning and Memory of Rats
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 441
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شناسه ملی سند علمی:
NIMED03_176
تاریخ نمایه سازی: 7 آبان 1398
چکیده مقاله:
We investigated the effects of feeding vitamin C (Vit C) during neonatal and juvenile growth on learning and memory of rats. Rats after delivery were randomly divided into four groups and treated. Materials and Methods: Rats after delivery were randomly divided into four groups and treated. Group 1, control group received normal drinking water. Groups 2-4 received Vit C 10, 100, and 500 mg/kg, respectively, from the first day. After 8 weeks, 10 male offspring of each group were randomly selected and tested in the Morris water maze (MWM) and passive avoidance (PA) tests. Finally, the brains were removed for biochemical measurement. Results: In MWM, 10-500 mg/kg Vit C reducedthe latency and traveled distance and increased time spent in the target quadrant. In PA, 10 and 100 mg/ kg of Vit C increased the latency; 10-500 mg/kg of Vit C decreased the malondialdehyde (MDA) in the brain tissues and increased thiol and catalase (CAT) activity compared to the control group. Conclusion: We showed that feeding rats Vit C during neonatal and juvenile growth has positive effects on learning and memory.
نویسندگان
Masoumeh Gholami
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Mahmoud Hosseini
Department of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Farimah Beheshti
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran