Manganese and Neuroinflammation
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 309
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شناسه ملی سند علمی:
NIMED03_241
تاریخ نمایه سازی: 7 آبان 1398
چکیده مقاله:
There are a few toxins can cause neuroinflammation in the environment. One of these toxins is manganese as a toxic metal in some doses.This study try to find the neurological effects of manganese in the neuroinflammation field. In some references researchers studied about the neurological effects of toxic metals such as lead and mercury but a few worked about the manganese. Toxicological and environmental medicine references had been reviewed such as agency for toxic substances and disease r egistry and environmental protection agency. These are showed neurological effects of manganese in moderate to high doses of exposure. Specially inhalational exposure in the environment and workplace. Manganese can cause neuroinflammation, synaptic injury, neurotransmitter disturbances, parkinsonism and parkinson’s disease. The patient has tremors, disruption of movement, problems in walking and rigidity. Prevention is included use of perfect ventilation systems and suitable respirators with specific cartridge in inhalational exposure. Prevention of eating or swallowing things with moderate to high dose of manganese and it’s compound. Prevention of skin contact by attention to hygiene guidance and wearing of specific gloves. If the patient is diagnosed in early stage of toxicity he or she get out from exposure and will be healthy. Screening of toxicity by biologic monitoring must be recommended. Blood sample in specific and periodic times can be helpful for this reason.Conclusion: Manganese can cause neuroinflammation and damage synaptic activity and neuronal disruptions. Prevention of exposure to moderate to high level of manganese must be implemented
نویسندگان
Seyedeh Negar Assadi
Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran