A Brief Description about Alzheimer’s Disease and Gene Therapy

Alzheimer’s disease is a neurodegenerative disorder. Neuropathologic symptoms of Alzheimer’s are extracellular amyloid plaques and intracellular phosphorylation of tau proteins. Gene therapy is a new form of molecular medicine will have a great impact on human’s health in the next century. A gene therapy technique mediated by a vector-driven genes, transfer DNA or RNA to target cells and increase the expression of therapeutic proteins or protectors, sometimes silence certain virulence genes. Gene delivery and stable production is the Achilles Heel in gene therapy methods. Since amyloid-β is continuously produced in the brain, the amount of production and degradation of itshould be reached stable. Gene therapy can directly increase enzymatic activity, through the transfer of a recombinant gene by the vector. Most vectors are viruses and the gene is expressed within it. One types of gene therapy is gene transferring to engineered cells and then inject them into the central nervous system. The unclear Alzheimer’s main pathogen is one of the limitations of gene therapy. An effective genetherapy needs seeking for main target genes. With the completion of the human genome project and the discovery of important genes, we are nearly close to the definitive Alzheimer’s treatment. Exception of safety, other important aspects of gene therapy for alzheimer’s include the correct gene dosage and the proper targeting of gene expression. Conclusion: More recognition of viruses, let us improve and modify highly site‐specific expression and adjustable expression level