Review of the Anti-Inflammatory Effect of Antioxidants on Multiple Sclerosis

Multiple sclerosis (Ms) is a chronic autoimmune disease in the central nervous system, which is a demyelinating disorder due to myelin involvement. It affects more than 2.3 million people in the world, often aged between 20- 40, and is increasing among the youngpopulation. The underlying cause of MS is still unclear. However, genetic factors, environmental contamination, and the E-B virus are among the factors mentioned. Research conducted in recent years suggests that the main causes of nerve scarring, can be free radicals suchas reactive oxygen species (ROS) and reactive nitrogen species (RNS). The source of (ROS) and (RNS) can be the intrinsic factors, such as mitochondrial activity, phagocytic cells or external factors such as contamination, tobacco smoke, heavy metals, some drugs LikeHalothane. The human body with antioxidant enzymatic and non-enzymatic systems cleans up these agents. free radicals, especially ROS, in case of excessive growth in the body, cause nerve inflammation in the site, and in addition to increasing monocytes and Macrophages itcauses functional impairment in the blood-brain barrier (BBB). On the other hand, these factors increase Tcell and Bcell and ultimately lead to demyelination. The research materials were extracted from SID, Science Direct, Google Scholar from 20 papers using MultipleSclerosis, Neuronal Inflammation, Oxidative Stress, Demyelination, Antioxidant therapy. Conclusion: External antioxidants such as flavonoids, Carotenoid, selenium, etc. can help the body’s antioxidant systems to more effectively remove the free radicals from the body,so antioxidants, by their anti-inflammatory properties, reduce the rate of demyelination and degradation in the area. These materials also modify immune system activity and prevent frequent attacks of the immune system to the nerves. According to the statement, the useof appropriate antioxidants can be useful in treating MS.