The Study of Neural Stem Cells Improve Cognition Via BDNF in a Transgenic Model of Alzheimer Disease

Alzheimer, is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time. It is the cause of 60–70% of cases of dementia. Neural stem cell (NSC) transplantation represents an unexplored approach for treating neurodegenerativedisorders associated with cognitive decline such as Alzheimer disease (AD). NSC transplantation can improve function by providing missing or defective enzymes or modulating inflammation. used aged triple transgenic mice (3xTg-AD) that express pathogenic forms of amyloid precursor protein, presenilin, and tau to investigate the effect of neural stem cell transplantation on AD-related neuropathology and cognitive dysfunction. hippocampal neural stem cell transplantation rescues the spatial learning and memory deficits in aged 3xTg- AD mice. Remarkably, cognitive function is improved without altering Aß or tau pathology. Instead, the mechanism underlying the improved cognition involves a robust enhancement of hippocampal synaptic density, mediated by brain-derived neurotrophic factor (BDNF). BDNF is decreased within the brains, serum, and CSF of patients with mild cognitive impairment and AD. lossof- function studies show that depletion of NSC-derived BDNF fails to improve cognition or restore hippocampal synaptic density. Conclusion: neural stem cells can ameliorate complex behavioral deficits associated with widespread Alzheimer disease pathology via BDNF. The aim of study is to try Clinical trial of this article.