A Patient with Combined Central and Peripheral Demyelination: A Case Report

Inflammatory demyelinating diseases are, in general, a group of disorders caused by damage of myelin layer because of different factors, for example infections, genetic mutations or immune system’s out-of-proportion activation against neuronal myelin, which leads to damage to axons and other neural units. Demyelination causes functional disability for patient that impose notable economic and social burden on countries. Impairment of the neural system are usually limited to the central or peripheral nervous system. Combined central and peripheral demyelination (CCPD) is rather uncommon, and the current information is based on case reports. CCPD is a disease that should not be considered as a simple blend of multiple sclerosis (MS) and chronic inflammatory demyelinating polyneuropathy (CIDP), an adventitious immune mediated disorder of the peripheral nerves system characterized by continuous loss of sensory and motor operations, because most of the patients have homogeneous clinical and laboratory data. A suspected CCPD individual ought to get magnetic resonance imaging (MRI) of CNS and electrophysiological testing to acquire an exact analysis of clinical manifestations. Clinical features are caused by neural demyelination and abnormal nerve conduction, including cranial nerve damage, paralysis, brain and spinal cord lesions, abnormal deep tendon reflexes and optic nerve disturbances. The aim of this research was to investigate clinical and para clinical features of a patient admitted to Mashhad’s Ghaem hospital. The patient was 35 years old women suffering from quadriparesis, facial peripheral nerve damage andwhole body pain following flu-like symptoms. Multiple abnormal sub cortical and para ventricular patches have been reported in her brain MRI. Conclusion: According to the patient’s situation, CCPD has serious and annoying clinical complications for the patient. Therefore, we need to use appropriate diagnostic methods for early diagnosis and minimum complications.