The Effect of Stem Cell Transplantation in the Treatment of Parkinson’s

Parkinson’s disease (PD) is a neurogenic disorder that causes movement disorders in humans. Standard therapies and former therapies, such as Levodopa prescription, can not prevent the development of the disease and control long-term motor symptoms However, cell therapy can have a potential impact on the disease. With the search in this review study on Google scholar and Pubmed databases, 77 papers agreed with entry filters, which were reviewed by title and abstracts of articles from 21 articles between 2014 and 2019 and targeted studies. The results showed that due to the ability of the brain to respond to disorders and restore the population of damaged neurons in the adult mammalian brain, Stem / progenitor cells have a potential role in restoring CNS damage. However, the transplantation of adipose-derived stem cells (ADSCs), Mesenchymal stem cells (MSCs), Human dental pulp stem cells (HDPSCs), Embryonic Stem Cells (ESCs) and Induced Pluripotent Stem Cells (IPSCs) in animal and human models Due to their ability to activate microglia, damaged tissue germination, migration capacity andhaving anti-inflammatory, immunomodulatory and neurodegenerative properties, they can be effective in slowing the PD process. Also, RHO kinase inhibitors (Rock), due to their effects on stabilizing axons of damaged neurons, protecting neuron death, and the backwardness of axon and biological nanoparticles, also increase the survival of stem cell transplantation and improve the delivery of cell to brain. They can be useful before and after transplantation of stem cells. In these studies, stem cell transplantation can slow down or stop Parkinson’s disease. Conclusion: Also, RHO kinase inhibitors and biological nanoparticles can help with the treatment of this disease. Of course, timely diagnosis isvery effective in the recovery process improve the delivery of cell to brain. They can be useful before and after transplantation of stem cells. In these studies, stem cell transplantation can slow down or stop Parkinson’s disease. Conclusion: Also, RHO kinase inhibitors and biological nanoparticles can help with the treatment of this disease. Of course, timely diagnosis is very effective in the recovery process