Comparative study on anti-inflammatory effect of aqueous extract of Cuminum cyminum L. and combination of Cuminum aqueous extract with gold and silver nanoparticles in formalin inflammatory model in ma

Background and Aim : ): Inflammation is the body s initial response to injuries or infections. Formalin test is a valuable method to assess inflammatory pains. Nowadays, recognition and development of anti-inflammatory drugs from plant origin have drawn a great attention. Cuminum cyminum L. has anti-inflammatory potentials. Nanotechnology has been widely used in different medical fields. One of them, is their application in inflammatory situations. The present study was carried out to examine and compare the anti-inflammatory effect of aqueous extract of Cuminum cyminum L. and mixture of aqueous extract of Cuminum with gold and silver nanoparticles in a formalin inflammatory model.Methods : this study was conducted on a total of 60 rats. 200, 500, and 1000 mg/kg of aqueous extract of Cumin, 200, 500, and 1000 mg/kg mixture of Cumin aqueous extract with gold/ Silver nanoparticles were prepared and were prescribed intraperitoneally. Formalin was injected in rat paw to induce inflammation and the produced inflammation was measured using Yoon method. Data analysis was performed using one-way ANOVA test.Results : Injection of Cumin aqueous extract at three different concentrations was shown to have no significant acute and chronic anti-inflammatory effect. injection of mixture of Cumin aqueous extract with AuNPs was shown to significantly reduce acute inflammation. Also, injection of mixture of 200 and 500mg Cumin aqueous extract with AgNPs significantly reduced acute and chronic inflammation.Conclusion : results of the present study suggest that mixture of Cumin aqueous extract with AgNPs or AuNPs have anti-inflammatory effect against acute and chronic inflammation.

کلیدواژه ها:

acute inflammation ، formalin ، chronic inflammation ، Cuminum ، gold nanoparticles ، silver nanoparticles ، aqueous extract