Assessment of Cinnamomum zeylanicum extracts pre-nutrition on antioxidant capacity after brain Ischemia in receiving high-fat diet rats

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 546

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شناسه ملی سند علمی:

NSCMED08_245

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Stroke is a cerebrovascular accident that occurs due to ischemia or blood vessel damage. This complication is the second leading cause of death after cancer and heart disease in Iran. Although the incidence of stroke is high, the approved effective therapies are limited. An antioxidant-rich diet is one of the most cost-effective methods for preventing stroke. Cinnamon is rich in antioxidants and according to the previous studies, the anti-inflammatory, anti-hyperlipidemia, anti-diabetic and neuroprotective effects of cinnamon have been proven. In this study, the pre nutritional effect of hydroalcoholic extract of cinnamon on the antioxidant capacity was studied after cerebral stroke induction in animals under a high-fat diet.Methods : In this study, 84 male Wistar rats were randomly divided into 7 groups(n=12): sham, control, model, lovastatin (10 mg/kg), vehicle (CMC 0/5%), high dose cinnamon (260 mg/kg) and low dose cinnamon (130 mg/kg). All groups except the control were on a high-fat diet for 8 weeks. Then, positive control, vehicle, low and high dose cinnamon groups received lovastatin, Carboxymethyl cellulose (CMC) and cinnamon extract 130 and 260 mg, respectively (6 weeks). At the end of the week 14th, treatment groups underwent MCAO surgery and 12 hours after the induction of stroke, antioxidant capacity was evaluated. The activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and the total antioxidant capacity (TAC) were determined.Results : The results of antioxidant activities of the cinnamon hydroalcoholic extract showed that total antioxidant capacity (TAC) and activity of superoxide dismutase and catalase (SOD and CAT) antioxidant enzymes were significantly increased at doses of 130 and 260 mg (P <0/05).Conclusion : Consumption of cinnamon extract increased serum antioxidant capacity in mice receiving a high-fat diet. Given the increase in free radicals after ischemic stroke, cinnamon intake seems to be effective in reducing the complications of a stroke.

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نویسندگان

Masoud Hatami Morassa

Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Hossein Mostafavi

Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Hadi Feizi

Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Mohsen Alipour

Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Masoumeh Hosseini

Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran