Dietary intakes of antioxidants and IgG-NMO in patients with neuromyelitis optica; is there any correlation

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 318

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شناسه ملی سند علمی:

NSCMED08_328

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Neuromyelitis optica (NMO) is a severe relapsing inflammatory CNS demyelinating disease that predominantly affects the optic nerves and spinal cord. The discovery of specific immunoglobulin G (IgG) antibodies binding to CNS astrocytic membranes identified the target as the water channel aquaporin-4 (AQP4) and Studies have demonstrated the pathogenic potential of these autoantibodies. Immune-mediated inflammation and oxidative stress are involved in the pathology of autoimmune disease, and dietary antioxidants have the potential to alleviate autoimmune disease symptoms by targeting inflammation and immune modulation.The aim of This study was to investigate the relation between dietary intakes of antioxidants and IgG-NMO titration in serum.Methods : Dietary intake of antioxidant components (vitamin E, Vitamin C, zinc, selenium, beta-carotene and alpha-tocopherol) were assessed with food frequency questionnaire (FFQ) with 168 items and investigate with IgG-NMO titration in 29 patients with NMO.Results : IgG-NMO titration in 9 patients was positive and in others was negative. Dietary intakes in all components of antioxidants, in patients with negative IgG-NMO was more than in patients with positive IgG-NMO but only dietary intakes of vitamin C was significant between patients with positive and negative IgG-NMO (p= 0. 033) and in others components does not significant different between two groups. Age and gender were not confounder variables.Conclusion : Physiological variation in dietary intakes of antioxidants may exert a major impact on IgG-NMO synthesis and inflammation in patients with NMO and antioxidants may dose play role in prognosis of NMO.

نویسندگان

Mohammad Bagher Maljaei

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Vahid Shaygannejad

Isfahan Neuroscience Research Center and Department of Neurology, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Omid Mirmosayyeb

Isfahan Neuroscience Research Center and Department of Neurology, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran