Evaluation of the preventive effects of Gallic acid on behavioral disorders and oxidative stress of brain following global cerebral ischemia/reperfusion in rats
محل انتشار: هشتمین کنگره علوم اعصاب و پایه و بالینی
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 377
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شناسه ملی سند علمی:
NSCMED08_346
تاریخ نمایه سازی: 15 دی 1398
چکیده مقاله:
Background and Aim : Global cerebral ischemia/reperfusion (I/R) may occur after any of several clinical conditions such as cardiac arrest and coma due to accident. In the present study we aimed to investigate the probable effects of gallic acid (GA) on spatial memory, depressive-like behavior, and oxidative stress induced by permanent arteria vertebralis heat-blocked and temporary carotid arteries occlusion/reperfusion (4VO) in rats.Methods : Fifty six male Wistar rats (250-300 g) were divided randomly into four groups; 1) Sham, 2) I/R, 3) GA + I/R and 4) Sham + GA. 4VO was induced after 10 days of pretreatment by GA. 72 h later 4VO induction behavioral tests, and oxidative stress evaluation were done.Results : The data showed that GA administration improved the spatial memory and depressive-like behavior in rats that were damaged by 4VO-I/R. In addition biochemical observations showed that the oxidative stress in the brain tissue were significantly improved in injured rats by 4VO-I/R who got GA (p <0.01).Conclusion : Our findings suggest that GA pretreatment can reverse behavioral disorders and reduce oxidative stress. These actions may induce by its antioxidant and anti-inflammatory properties.
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نویسندگان
Hamzeh Mirshekari Jahangiri
Physiology Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Golestan Blvd, Ahvaz, Iran
Alireza Sarkaki
Physiology Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Golestan Blvd, Ahvaz, Iran
Yaghoob Farbod
Physiology Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Golestan Blvd, Ahvaz, Iran
Mahin Dianat
Physiology Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Golestan Blvd, Ahvaz, Iran