The Effect of Vitamin C on Fear(avoiding) Memory in Isolated Stress Rats

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 298

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شناسه ملی سند علمی:

NSCMED08_524

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Social isolation of rats is a common model used to study the effects of isolation stress on behavior and brain activity. Furthermore, increased anxiety-like behaviors following isolation have been observed in the elevated plus maze, and shuttle-box tests. Social isolation decreased the activities of antioxidant enzymes catalase, glutathione peroxidase, superoxide dismutase, and the total antioxidant capacity, but increased levels of hydrogen peroxide, in certain brain regions, of which prefrontal cortex and hippocampus were most vulnerable. Therefore antioxidant components may through enhancment of antioxidant propertis may cause to improvement of memory and anxiety.Methods : 32 male Wistar rats (200-250g) were randomly divided into the four groups (n = 8) Control(CO), Isolation stress(IS), Control and vitamin C (Co+V) and Isolation stress and vitamin C (IS+V). In IS groups animals were housed individually in the cages for 21 days. In IS+V and CO+V groups animals were received vitamin C (500mg/kg) for 21 days and in CO and IS animals were received normal saline for 21 days by gavage. After that passive avoidance test was done for considering fear(avoiding) memoryResults : in CO+V and IS+V groups step-through latency was increased in comparison to the control and IS groups and also in CO+V and IS+V groups, the rate of stay in shock(dark) chamber was significantly decreased in CO+V and IS+V groups in comparison to the control and IS groupsConclusion : This study showed that isolation stress cause decrease in fear(avoiding) memory and vitamin C , repaired and improved this memory in isolation stress rat.

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نویسندگان

Zeinab Shakerin

pHD of Anatomical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Ali Najafdolabi

MD student, Isfahan University of Medical Sciences, Isfahan, Iran

Maede Ghasemi

Departments of physiological Sciences Isfahan University of Medical Sciences, Isfahan, Iran