Cornea Regeneration

Corneal reconstruction has dramatically progressed in recent years. stem cells. In bilateral total LSCD surgical options are keratolimbalallograft transplantation (KLAL), living-related conjunctival limbalallograft transplantation (lr-CLAL) and cultivated oral mucosal epithelialtransplantation (COMET). Stromal reconstruction includes penetratingkeratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK). Tissueengineering is more elementary in stromal reconstruction, however,the only proven clinical trial which is in progress is using collagenousbiomaterials. Endothelial reconstruction includes Descemet strippingautomated endothelial keratoplasty (DSAEK), Descemet membraneendothelial keratoplasty (DMEK) and endothelial cell culture.The cornea is the most important optical element of the eye. It hasthree main histologic parts; epithelium, stroma and endothelium. Allparts especially their stem cells may be destroyed by different offendingmechanisms. The type of epithelial regeneration depends on the severityand laterality of the lesion. In unilateral total limbal stem cell deficiency(LSCD) surgical alternatives include conjunctival limbal autograft(CLAU), cultivated limbal epithelial transplantation (CLET), simplelimbal epithelial transplantation (SLET) and in vivo cultivation of limbal

کلیدواژه ها:

Corneal reconstruction ، Limbal stem cells ، Cornea