Oral Manifestation and Dental Management: A case with Chronic Graft Versus Host Disease

Background and Aim: Chronic graft versus host disease is a potentiallytherapeutic procedure for patients with relapsed or refractoryhematological malignancies. This case is the first to report oralmanifestation and dental management in a patient with chronicgraft versus host disease after allogeneic hematopoietic stem celltransplantation with a long-term follow-up.Method: A 40-year-old man referred to the department with complaintsof tongue burning, mouth dryness, and ulcers was studied.Results: The patient had chronic myelogenous leukemia and hadundergone allogeneic hematopoietic stem cell transplantation. Thepatient had undergone treatment with several sessions of extracorporealphotopheresis. The graft versus host disease complications had startedabout nine months after hematopoietic stem cell transplantation.Conclusion: The dentist should play a role in the local therapy of caseswith oral manifestation and dental management of chronic graft versus host disease. Controlling the graft versus host disease can reduce oraland dental alterations, increase the improvement of the quality of life,and reduce the need for more intensive immunosuppressive systemictherapies.

کلیدواژه ها:

Hematopoietic stem cell transplantation ، Graft versus host disease ، Oral manifestation ، Dental management