Fas-AS Long Noncoding RNA and Acute Myeloid Leukemia

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 280

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شناسه ملی سند علمی:

NSCMRMED03_367

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: Recently, long noncoding RNAs (lncRNAs) havebeen noticed as potential predictive biomarkers for prognosis of differenthuman cancers. One example is the FAS-AS RNA 1 located in the10q23.31 region which is transcribed from the opposite strand of theFAS gene. FAS has a major role in the regulation of apoptotic pathwaysand there is a reverse correlation between FAS-AS1 expression level andproduction of the soluble form of Fas.Methods: So in this study, we assessed FAS-AS1 expression in bloodsamples of de novo AML patients and control subjects using qRT-PCR.Results: The result of this study showed that there is no significantdifference in FAS-AS1 lncRNA expression between AML patients andhealthy individuals.Conclusion: We conclude that FAS-AS1 is not an informative biomarkerfor AML diagnosis.

کلیدواژه ها:

Acute myeloid leukemia ، Long non- coding RNA ، FAS- AS1

نویسندگان

Mohammad Taheri

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hamid Fallah

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Iman Azari

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Arezoo Sayad

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran