Eugenol Molecularly Imprinted Polymer Nanoparticles as Novel Drug Carriers

Eugenol is a major constituent of clove essential oil; that is an organic phenol compound with antipyretic, analgesic, anti-inflammatory, anesthetic effects, antibacterial, antioxidant, antifungal, insect repellent, and anticancer activities. Minimizing eugenol side effects, with low toxicity, and non-metabolized residue, eugenol has wide application in foods, agriculture, pharmaceuticals, pesticides, cosmetics and dentistry. Eugenol is highly sensitive to light, temperature and air, which can limit its application and bioavailability. For the first time in this study, eugenol Molecular imprinted nanoparticles (MINPs) synthesized that is not toxic and is resistant to light, temperature and air as one possible alternative to the use of the eugenol. MINPs account for the large drug loading capacity and slow drug release behaviour as drug carriers. The MINPs was prepared by precipitation polymerization using eugenol as a template, methacrylic acid (MAA) as the functional monomer and trimethylolpropane trimethacrylate (TRIM) as the cross-linking agent and acetonitrile as progen. The produced polymers were characterized by scanning electron microscopy (SEM); Thermogravimetric/Differential Thermal Analysis (TGA/DTA). the drug loading and in vitro releasing property of eugenol MINPs were investigated. The obtained MINPs, 45 nm, had smooth surface and favourable dispersibility. The entrapment efficacy and drug loading capacity of eugenol loaded MINPs were 97.25% and 8.72% respectively. In PBS (pH7.4), MINPs showed sustained release behaviour. The MINPs in vitro release percentage reached about 70% during 216 h.

کلیدواژه ها:

Eugenol ، Molecular imprinted ، nanoparticles ، in vitro ، release