Study of Diclofenac drug release by PEG/NaY nanocomposites

Recently, hybrid materials using poly ethylene glycol and porous nanocrystal have been developed for drug release. In this study, poly ethylene glycol (PEG)/NaY zeolite nanocomposite get synthesized. This material is characterized using FT-IR spectroscopy, XRD, TGA and SEM. After loading the Diclofenac onto this nanocomposite, the release of Diclofenac was studied in two kinds of release fluids simulating body fluid KH2PO4-NaOHbuffer (pH=7.5) and gastric fluid (HCl aqueous solution, pH=2.5), while controlling the time, pH values, and temperature using UV-Vis. The effect of pH and temperature values on the release amount of loaded-drug was evaluated in different pH (2.5-9) and different temperatures (37-40°C) at certain time intervals by UV–Vis spectrophotometer.Thebehavior of drug release in this nanocomposite is probably due to hydrogen bonding interactions between drug and the hydroxyl group on the composite framework.

کلیدواژه ها:

PEG/NaY ، Diclofenac ، Release