Does diabetes aggravate carpal tunnel release outcome among patients suffering from carpal tunnel syndrome

BackhroundsCarpal tunnel syndrome (CTS) is one the most common upper extremity conditions,mostly affects women. Management of patients suffering from both CTS and diabetesis challenging as diabetes affects diagnosis as well as treatment. Since the result ofsurgical treatment in coexistence of CTS and diabetes in contrast to idiopathic CTS isunclear, the aim of this study was to compare the results of CTS treatment in diabeticpatients with non-diabetic patients.Methods: Our meta- analysis had been done based on the Preferred Reporting Itemsfor Systematic Reviews and Meta-Analysis (PRISMA) statement. First, databasessearches were done followed by primary identification, removing duplication, and abstract screening which were performed by two different researchers. After thatanalysis was performed using CMA® (comprehensive meta- analysis) software(version 2.0).Results: In our systematic research, two relevant studies were found using QuickDASH. There was no statistically significant difference between two studies regardingpostoperative Quick DASH scores (P- value= 0.112). Analyzing the studies which usedBCTS revealed that both the functional status and symptom severity status scores werestatistically different between studies (FSS p-value= < 0.001, SSS p-value= < 0.001).Also, all the nerve conduction parameters were statistically significant, except for MCVamong diabetic and nondiabetic patients after carpal release (P value= 0.091).Conclusions: Our study revealed that diabetes negatively affects the final results ofcarpal tunnel release operation such as severity of symptoms, function, and nerveconduction study results. Since various external factors contribute in diabetics’ carpaltunnel release surgery, their treatment should include both the external (ischemia,hyperglycemia, and growth factor deficiency) and internal (anatomical) factors.