The evaluation of the effect of cyclogest in comparison with placebo in threatened preterm labour at 24-32 weeks of gestation
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 362
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شناسه ملی سند علمی:
PNMED07_052
تاریخ نمایه سازی: 18 تیر 1398
چکیده مقاله:
Background: The efficacy of maintenance tocolytic therapy after successful arrest of preterm labour remains controversial. The purpose of this study was to evaluate the efficacy of 400 mg of daily vaginal progesterone (cyclogest) after successful parenteral tocolysis to and Methods: In this randomised, double-blind, placebo-controlled trial, 85 participants were randomly allocated to either 400 mg daily of vaginal progesterone or placebo until 34 weeks of gestation. The primary outcomes were the time until delivery (latency period) and cervical length after one week of treatment. Secondary outcome were GA on delivery, type of delivery, incidence of low birth weight, perinatal morbidity and mortality.Results: Longer mean latency until delivery (53.6±16.8 vs 34.5±12.9) days P=0.0001; longer mean of gestational age on delivery (37.5±2.2 vs 34.2±2.1) weeks P=0.0001; cervical length after one week of treatment (27.5±5.5 vs 20.7±3.1) mm P=0.0001; low birth weight 12 (29.3%) vs 19 (57.6%) P = 0.01; and NICU admission 9 (22%) vs 15 (45.5%), were significantly different between the two groups. No significant differences were found between neonatal death 1 (2.4%) vs 2 (6.1%), P = 0.43; RDS 5 (12.2%) vs 8 (24.2%), P = 0.17; and need to mechanical ventilator 2 (5.4%) vs 6 (18.2%) P = 0.136, for the progesterone and placebo groups, respectively.Conclusion: Daily administration of 400 mg vaginal progesterone after successful parenteral tocolysis increases latency preceding delivery and improves cervical shortening and neonatal outcome in women with preterm labour.
کلیدواژه ها:
نویسندگان
Homeira Vafaei
Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Zare khafri
Maternal-Fetal Medicine Research Center, OB & GYN Ward, Shiraz University of Medical Sciences, Shiraz, Iran
Nasrin Asadi
Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Kasraeian
Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran,