The effect of nanoadditives on viscoelastic parameters of bioadhesive gels composed of cellulose derivatives

Bioadhesives are natural or synthetic polymeric materials that designed as adhesives and controlled drug delivery systems for biological tissues. The interaction parameter of bioadhesive polymers is an important property that improves theefficiency of controlled drug delivery systems. The difference between storage modulus of bioadhesives and a single component leads to the interaction parameter increasing; therefore, increasing storage modulus of bioadhesives causes the efficiency improvement of these systems in contact to mucus. In this study the effect of nanoadditive powders (type and concentration) and frequency on viscoelastic parameters ofbioadhesives composed of interactive polymer gels is examined. The bioadhesive composed of microcrystalline cellulose(MCC) and sodium carboxymethylcellulose (NACMC). The rheological characterization of this system was performed by using oscillatory rheometery.Three types ofhigh consumptionnanoadditives as drug carriers(nanoclay,nanosilica and nanostarch powders) in controlled drug delivery systems are used in this investigation. The D-optimal method is utilized for designof experiment and finallyby using this method effect of these variables on viscoelastic parameters was analyzed. This bioadhesive in all concentrations and types of nanoadditives exhibited constant viscosity; therefore,it was suitable for controlled drug delivery systems in contact to biological tissues.Based on the rheological experiments and analysis of variance (ANOVA), it is found that nanoadditive type, concentration and binary interaction of these variables have higher effect on bioadhesive efficiency and variables of experiment have higher positive effect on efficiency of bioadhesive composed of nanoclayin comparison to other additives.